[HTML][HTML] Enhancing therapeutic approaches for melanoma patients targeting epigenetic modifiers

M Gracia-Hernandez, Z Munoz, A Villagra - Cancers, 2021 - mdpi.com
Epigenetic alterations can also lead to immune evasion and … to treat patients that do not
respond or become resistant to first… molecules in melanoma cells and decreased tumor growth in …

[HTML][HTML] Molecular characterization of the clinical and tumor immune microenvironment signature of 5-methylcytosine-related regulators in non-small cell lung cancer

T Liu, L Guo, G Liu, X Hu, X Li, J Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
… For background correction and normalization, the Robust … of immunotherapy outcomes.
However, the survival analysis … Epigenetic alterations are associated extensively with the …

Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: an Italian melanoma intergroup study

…, P Queirolo, Italian Melanoma Intergroup (IMI) - … , Immunotherapy, 2019 - Springer
… among patients in irCR/irPR (immune-related complete/partial … However, the benefit in terms
of long-lasting disease control … (ALC) [18], and epigenetic features of melanoma and tumor

Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab

MP Pistillo, R Carosio, F Grillo, V Fontana… - Clinical …, 2020 - Elsevier
Molecular and epigenetic features of melanomas and tumor immune microenvironment
linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

[HTML][HTML] Genetic and epigenetic biomarkers of immune checkpoint blockade response

Q Xiao, A Nobre, P Piñeiro… - Journal of clinical …, 2020 - mdpi.com
… of JAK family members render melanoma resistant to IFN-γ … be related to progressive disease
in melanoma patients. … of the anti-tumor immune reactivation could be related to the post-…

[HTML][HTML] Molecular immunotherapy: promising approach to treat metastatic colorectal cancer by targeting resistant cancer cells or cancer stem cells

S Forster, R Radpour - Frontiers in oncology, 2020 - frontiersin.org
… response, they are associated with virtually no activity in patients with pMMR/… remission
rates in metastatic CRC (60). Recently, modern molecular analysis has shown that melanoma

[HTML][HTML] … profiles differ in responders versus non-responders to anti-PD-1 immune checkpoint inhibitors in patients with advanced and metastatic head and neck …

AM Starzer, G Heller, E Tomasich… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
… genes involved in cancer-related molecular pathways. Over-… potential of durable responses,
immune-related side effects … Due to clinical indications in our patients the first radiological …

Network for biomarker immunoprofiling for cancer immunotherapy: cancer immune monitoring and analysis centers and cancer immunologic data commons (CIMAC …

HX Chen, M Song, HT Maecker, S Gnjatic… - Clinical Cancer …, 2021 - AACR
… Furthermore, biomarkers to predict immune-related adverse … measures epigenetic changes
in sorted specific immune cell … prevention, and treatment of melanoma using PD-L1 isoforms …

Lower expression of GBP2 associated with less immune cell infiltration and poor prognosis in skin cutaneous melanoma (SKCM)

S Zhang, K Chen, Z Zhao, X Zhang, L Xu… - … of Immunotherapy, 2022 - journals.lww.com
… of the immune microenvironment, 7 and tumor antigens can … molecular markers of immune
infiltration cells and negatively … modifications, which can be as a crucial epigenetic regulator of …

Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease

L Penter, Y Liu, JO Wolff, L Yang, L Taing, A Jhaveri… - Blood, 2023 - ashpublications.org
… cutis samples from patients with durable remission after ipilimumab … , bladder cancer, and
metastatic melanoma, recently … of response to ipilimumab-based therapy. Consistent with …